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Droplet Digital PCR ddPCR , a recently developed technique with high sensitivity and specificity, was used in this study to evaluate the association between the abundance of ALK rearrangements and crizotinib effectiveness. FFPE tissues were obtained from consecutive patients with lung adenocarcinoma. The results revealed that 14 Two of them responded well to crizotinib after unsuccessful chemotherapy.

Published by Elsevier Inc. Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma. Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, comprising childhood and adult tumours encompassing all major histological subtypes.

These findings may inform patient selection in future trials of IGF1R inhibitors in osteosarcoma. This process operates recurrently at discrete genomic regions and generates driver mutations. Lastly, it may represent an age-independent mutational mechanism that contributes to the development of osteosarcoma in children and adults alike.

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL- rearranged leukemias. Six cases harbored NPM1 mutations, with each case lacking common cytogenetic abnormalities. As dysregulated homeobox gene expression is also a feature of MLL- rearranged leukemia, the gene expression signatures of NPM1-mutated and MLL- rearranged leukemias were compared.

Consugar, Mark B. PKD1 is located in an intrachromosomally duplicated region. To rapidly identify large rearrangements , a multiplex ligation-dependent probe amplification assay was developed employing base-pair differences between PKD1 and the six pseudogenes to generate PKD1-specific probes. Characterization of a family found to be mosaic for a PKD1 deletion is discussed here to illustrate family risk and donor selection considerations.

Heterokaryon vegetative incompatibility, governing the fusion of somatic hyphal filaments to form stable heterokaryons, is of interest because of its widespread occurrence in fungi and its bearing on cellular recognition. Conventional investigations of the genetic basis of heterokaryon incompatibility in N. This difficulty is overcome by using duplications partial diploids that are unlikely to contain more than one het locus.

A phenotypically expressed incompatibility reaction occurs when unlike het alleles are present within the same somatic nucleus, and this parallels the heterokaryon incompatibility reaction that occurs when unlike alleles in different haploid nuclei are introduced into the same somatic hypha by mycelial fusion. This was demonstrated for three loci which had previously been established by conventional heterokaryon tests—het-e, het-c and mt.

These were each obtained in duplications as recombinant meiotic segregants from crosses heterozygous for duplication-generating chromosome rearrangements. The particular method of producing the duplications is irrelevant so long as the incompatibility alleles are heterozygous. In laboratory strains both loci are represented simply by two alleles. Analysis of het-c is more complicated in some wild strains, where differences have been demonstrated at one or more additional het loci within the duplication used and multiple allelism is also possible.

In this case, a deletion encompassing the last intron and part of exon 15 of MYB, including the binding site of ERG-1, a transcription factor that may downregulate MYB, and the exon 15 splice site, was detected. Establishment and characterization of scleroderma fibroblast clonal cell lines by introduction of the hTERT gene.

Abstract Lack of an adequate experimental model has hindered the ability to fully understand scleroderma SSc pathogenesis. Current SSc research is based on the study of cultured fibroblasts from skin biopsies. In depth characterization of the SSc fibroblast phenotype is hindered by the limited lifespan and heterogeneity of these cells. The goal of this study was to isolate high collagen-producing fibroblasts from SSc biopsies and extend their lifespan with hTERT immortalization to enable characterization of their phenotype.

Infected colonies were isolated, cultured into clonal cell lines and analysed with respect to profibrotic gene expression. Protein levels were assessed by Western blot. A subset of the SSc clones showed elevated expression levels of collagen I, connective tissue growth factor and thrombospondin 1 mRNA, while expression of other genes was not significantly changed.

Elevated expression of collagen I protein and mRNA was correlative with elevated expression of connective tissue growth factor. A portion of SSc clones expressed several profibrotic genes. This study demonstrates that select characteristics of the SSc phenotype are expressed in a subset of activated fibroblasts in culture. The clonal SSc cell lines may present a new and useful model to investigate the mechanisms involved in SSc fibrosis.

Lack of an adequate experimental model has hindered the ability to fully understand scleroderma SSc pathogenesis. Comparative linkage mapping of genes on sheep chromosome 3 provides evidence of chromosomal rearrangements in the evolution of the Bovidae. The order and genetic distances between loci on OAR 3 are similar to those on cattle Bos taurus chromosome 5, as expected from their close evolutionary relationship.

The OAR 3 linkage map shows conserved synteny with human chromosome 12, but there are at least two rearrangements in gene order between the species. We use full mitochondrial genomes to test the robustness of the phylogeny of the Octocorallia, to determine the evolutionary pathway for the five known mitochondrial gene rearrangements in octocorals, and to test the suitability of using mitochondrial genomes for higher taxonomic-level phylogenetic reconstructions. Our phylogeny supports three major divisions within the Octocorallia and show that Paragorgiidae is paraphyletic, with Sibogagorgia forming a sister branch to the Coralliidae.

Furthermore, Sibogagorgia cauliflora has what is presumed to be the ancestral gene order in octocorals, but the presence of a pair of inverted repeat sequences suggest that this gene order was not conserved but rather evolved back to this apparent ancestral state. Based on this we recommend the resurrection of the family Sibogagorgiidae to fix the paraphyly of the Paragorgiidae. This is the first study to show that in the Octocorallia, mitochondrial gene orders have evolved back to an ancestral state after going through a gene rearrangement , with at least one of the gene orders evolving independently in different lineages.

A number of studies have used gene boundaries to determine the type of mitochondrial gene arrangement present. However, our findings suggest that this method known as gene junction screening may miss evolutionary reversals. Additionally, substitution saturation analysis demonstrates that while whole mitochondrial genomes can be used effectively for phylogenetic analyses within Octocorallia, their utility at higher taxonomic levels within Cnidaria is inadequate.

Therefore for phylogenetic reconstruction at taxonomic levels higher than subclass within the Cnidaria, nuclear genes will be required, even when whole mitochondrial genomes are available. Octocoral mitochondrial genomes provide insights into the phylogenetic history of gene order rearrangements , order reversals, and cnidarian phylogenetics.

Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not MLL gene. The translocations included t X;11 p Five of six patients with acute leukaemia had received chemotherapy and detection of 11q23 translocation occurred at time of disease relapse. All patients received risk-adapted therapies, including stem cell transplant in five patients. Murphy, Danielle A. Targeted therapy combined with companion diagnostics has led to the advancement of next-generation sequencing NGS for detection of molecular alterations.

However, using a diagnostic test to identify patient populations with low prevalence molecular alterations, such as gene rearrangements , poses efficiency, and cost challenges. We demonstrate that the NGS assay is accurate and reproducible in identification of gene rearrangements. Furthermore, implementation of an RNA quality control metric to assess the presence of amplifiable nucleic acid input material enables a measure of confidence when an NGS result is negative for gene rearrangements.

Together, this 2-step assay is an efficient method for detection of gene rearrangements in both clinical testing and studies of archival formalin-fixed paraffin-embedded specimens. Previous studies of the Sleeping Beauty SB transposon system, as an insertional mutagen in the germline of mice, have used reverse genetic approaches. These studies have led to its proposed use for regional saturation mutagenesis by taking a forward-genetic approach.

Thus, we used the SB system to mutate a region of mouse Chromosome 11 in a forward-genetic screen for recessive lethal and viable phenotypes. This work represents the first reported use of an insertional mutagen in a phenotype-driven approach. The phenotype-driven approach was successful in both recovering visible and behavioral mutants, including dominant limb and recessive behavioral phenotypes, and allowing for the rapid identification of candidate gene disruptions.

In addition, a high frequency of recessive lethal mutations arose as a result of genomic rearrangements near the site of transposition, resulting from transposon mobilization. The results suggest that the SB system could be used in a forward-genetic approach to recover interesting phenotypes, but that local chromosomal rearrangements should be anticipated in conjunction with single-copy, local transposon insertions in chromosomes.

Additionally, these mice may serve as a model for chromosome rearrangements caused by transposable elements during the evolution of vertebrate genomes. Pseudoscorpion mitochondria show rearranged genes and genome-wide reductions of RNA gene sizes and inferred structures, yet typical nucleotide composition bias. Background Pseudoscorpions are chelicerates and have historically been viewed as being most closely related to solifuges, harvestmen, and scorpions.

No mitochondrial genomes of pseudoscorpions have been published, but the mitochondrial genomes of some lineages of Chelicerata possess unusual features, including short rRNA genes and tRNA genes that lack sequence to encode arms of the canonical cloverleaf-shaped tRNA. Additionally, some chelicerates possess an atypical guanine-thymine nucleotide bias on the major coding strand of their mitochondrial genomes.

Results We sequenced the mitochondrial genomes of two divergent taxa from the chelicerate order Pseudoscorpiones. Indeed, in one genome, all 22 tRNA genes lack sequence to encode canonical cloverleaf structures. We also find that the large ribosomal RNA genes are substantially shorter than those of most arthropods. We inferred secondary structures of the LSU rRNAs from both pseudoscorpions, and find that they have lost multiple helices. Based on comparisons with the crystal structure of the bacterial ribosome, two of these helices were likely contact points with tRNA T-arms or D-arms as they pass through the ribosome during protein synthesis.

The mitochondrial gene arrangements of both pseudoscorpions differ from the ancestral chelicerate gene arrangement. One genome is rearranged with respect to the location of protein-coding genes , the small rRNA gene , and at least 8 tRNA genes.

The other genome contains 6 tRNA genes in novel locations. Most chelicerates with rearranged mitochondrial genes show a genome-wide reversal of the CA nucleotide bias typical for arthropods on their major coding strand, and instead possess a GT bias. Yet despite their extensive rearrangement , these pseudoscorpion mitochondrial genomes possess a CA bias on the major coding strand. Phylogenetic analyses of all In order to study the clonal relationship and blaKPC gene detection in clinical isolates of Klebsiella pneumoniae resistant to carbapenems, we analyzed 22 clinical isolates of K.

Susceptibility to different antimicrobials was determined, and the presence of carbapenemases was detected by modified Hodge method, phenyl boronic acid synergy and combination discs. High rates of antimicrobial resistance were found, five strains were negative, at least one phenotypic method, and all carried the blaKPC gene.

Clonal spread was observed only in the intensive care unit ICU , while in other services, polyclonality was found. We concluded that blaKPC gene is present in K. Rearrangement of a large novel Pseudomonas aeruginosa gene island in strains isolated from a patient developing ventilator-associated pneumonia.

Bacterial gene islands add to the genetic repertoire of opportunistic pathogens. Here, we perform comparative analyses of three Pseudomonas aeruginosa strains isolated sequentially over a 3-week period from a patient with ventilator-associated pneumonia VAP who received clindamycin and piperacillin-tazobactam as part of their treatment regime.

While all three strains appeared to be clonal by standard pulsed-field gel electrophoresis, whole-genome sequencing revealed subtle alterations in the chromosomal organization of the last two strains; specifically, an inversion event within a novel kb gene island PAGI 12 composed of open reading frames [ORFs]. Predicted ORFs in the island included metabolism and virulence genes. Examination of a separate cohort of 76 patients with VAP for integration at this tRNA lys recombination site demonstrated that patients exhibiting evidence of integration at this site had significantly higher day mortality.

These findings provide evidence that P. All Rights Reserved. Singh, G. Examination of a separate cohort of 76 patients with VAP for integration at this tRNAlys recombination site demonstrated that patients exhibiting evidence of integration at this site had significantly higher day mortality.

Hendrickx, Antoni P. Most Enterococcus faecium isolates associated with hospital outbreaks and invasive infections belong to a distinct genetic subpopulation called clonal complex 17 CC It has been postulated that the genetic evolution of CC17 involves the acquisition of various genes involved in antibiotic resistance, metabolic pathways, and virulence.

To gain insight into additional genes that may have favored the rapid emergence of this nosocomial pathogen, we aimed to identify surface-exposed LPXTG cell wall-anchored proteins CWAPs specifically enriched in CC17 E. Expression at the mRNA level was demonstrated, and immunotransmission electron microscopy revealed an association of the five LPXTG surface proteins with the cell wall.

Clonal expansion of T-cell receptor beta gene segment in the retrocochlear lesions of EAE mice. It has been reported that the T cell receptor V beta 8. We have demonstrated retrocochlear hearing loss in EAE mice in previous studies. Administration of a monoclonal antibody specific to the T cell receptor V beta 8 TcrbV8 subfamily prevented both this type of hearing loss and the central nerve disease.

In this study, we examined the role of the TcrbV8. A clonal expression of T cell receptor beta chain gene segment TcrbV8. The TcrbV8. The TcrbJ2. Only TcrbD2, with a length of 4 amino acids, was observed recombining with these TcrbV8.

This dominant TcrbV gene segment TcrbV8. These results suggest that a small subset of antigen-specific T cells migrate to, and expand at, the retrocochlear lesions, which leads to hearing loss. Cytomorphology of non-small cell lung carcinoma with anaplastic lymphoma kinase gene rearrangement. Cytogenetic analysis was performed with fluorescence in situ hybridization. A total of 12 patients were identified, 10 with available material.

Cellular morphology and smear background was evaluated in the study group, as well as control cases lacking ALK rearrangement. A total of 25 specimens from 10 patients were obtained. Biological valves usually are made from animal tissue. Full Text Available Aim.

To study the effect of transcatheter aortic valve implantation TAVI, performed by different types of prostheses and various surgical access, on the prognosis of patients with critical aortic stenosis and comorbidities. Material and methods. Complications including perioperative mortality, total day mortality, as well as post-hospital mortality were registered during aortic valve replacement, immediately after surgery, before the expiry of 30 days.

Mean follow-up was 2. Hospital mortality was on average 6. The number of deaths in the post-hospital period was Valve type and the type of access had no effect on post-hospital mortality. Men died more than 2. Atrioventricular block, pacemaker implantation, and history of chronic obstructive pulmonary disease were the most significant prognostic factors.

An important role of minor stroke and renal failure should be noted. Mortality did not depend on the surgical access or valve type. All parameters characterizing the intervention were significantly associated with mortality, both during and after surgery.

The proportion of survivors at the end of the first year of observation using Corvalve system was Two-year survival was TAVI is the method of choice, reasonable alternative approach for surgical valve replacement in patients with high surgical risk, although. Valve system incorporating single failure protection logic. A valve system incorporating single failure protective logic. The system consists of a valve combination or composite valve which allows actuation or de-actuation of a device such as a hydraulic cylinder or other mechanism, integral with or separate from the valve assembly, by means of three independent input signals combined in a function commonly known as two-out-of-three logic.

Ball check valve. A pressurized nuclear reactor having an instrument assembly sheathed in a metallic tube which is extended vertically upward into the reactor core by traversing a metallic guide tube which is welded to the wall of the vessel is described. Sensors in each instrument assembly are connected to instruments outside the vessel to manifest the conditions within the core. Each instrument assembly probe is moved into position within a metallic guide channel.

The guide channel penetrates the wall of the vessel and forms part of the barrier to the environment within the pressure vessel. Each channel includes a ball check valve which is opened by the instrument assembly probe when the probe passes through the valve.

A ball valve element is moved from its seat by the probe to a position lateral of the bore of the channel and is guided to its seat along a sloped path within the valve body when the probe is removed. Thermostatic Radiator Valve Evaluation.

Dentz, J. A large stock of multifamily buildings in the Northeast and Midwest are heated by steam distribution systems. Losses from these systems are typically high and a significant number of apartments are overheated much of the time.

Thermostatically controlled radiator valves TRVs are one potential strategy to combat this problem, but have not been widely accepted by the residential retrofit market. In this project, the ARIES team sought to better understand the current usage of TRVs by key market players in steam and hot water heating and to conduct limited experiments on the effectiveness of new and old TRVs as a means of controlling space temperatures and reducing heating fuel consumption.

Objective: Cardiac surgical mortality has improved during the last decade despite the aging of the population. An integrated US health plan developed a heart valve registry to track outcomes and complications of heart valve operations. This database was used for longitudinal evaluation of mitral valve MV outcomes from to at four affiliated hospitals.

Methods: We identified patients in the Apollo database who underwent initial MV procedures. Internal administrative and Social Security Administration databases were merged to determine survival rates. Electronic health records were searched to ascertain demographics, comorbidities, and postoperative complications. Cox regression was used to evaluate mean survival and identify risk factors. Results: The procedures included mechanical valve replacements, tissue valve replacements, and annuloplasties.

Mean survival was 8. Early in the study, there was a preference for implanting mechanical MVs. Beginning in , more patients received tissue valve replacements rather than mechanical valves. Over time, there was an increasing trend of annuloplasty. Cox regression analysis identified the following risk factors for increased ten-year mortality: tissue valve implantation; advanced age; female sex; nonelective, nonisolated procedure; diabetes; postoperative use of banked blood products; previous cardiovascular intervention; dialysis; and longer perfusion time.

Hospital location, reoperation, preoperative anticoagulation, and cardiogenic shock were not statistically significant risk factors. Conclusions: When controlling for other risk factors, we observed a lower long-term survival rate for tissue valve replacement compared with. Full Text Available Background: There have been a number of studies on mitral valve replacement and repeated percutaneous mitral balloon valvotomy for mitral valve restenosis after percutaneous mitral balloon valvotomy.

However, studies on mitral valve repair for these patients are rare. In this study, we analyzed postoperative outcomes of mitral valve repair for mitral valve restenosis after percutaneous mitral balloon valvotomy. Methods: In this study, we assessed 15 patients mean age, The mean interval between the initial percutaneous mitral balloon valvotomy and the mitral valve repair was The mean preoperative Wilkins score was 9.

Results: The mean mitral valve area obtained using planimetry increased from 1. The mean pressure half time obtained using Doppler ultrasound decreased from The mean pressure gradient obtained using Doppler ultrasound decreased from 9. There were no early or late deaths. Thromboembolic events or infective endocarditis did not occur. The 5-year event-free survival was Conclusion: On the basis of these results, we could not conclude that mitral valve repair could be an alternative for patients with mitral valve restenosis after percutaneous balloon mitral valvotomy.

However, some patients presented with results similar to those of mitral valve replacement. Further studies including more patients with long-term follow-up are necessary to determine the possibility of this application of mitral valve repair. Mitral valve replacement is the procedure of choice in patients with severe mitral valve disease. However, these patients are surviving longer and are thus at an increased risk of prosthesis failure or valve -related complications. Study population: All patients undergoing redo mechanical mitral valve replacement surgery between January and December Study design: Retrospective analysis of patients undergoing redo mitral valve replacement.

Patients were identified from theatre record books, their files were electronically accessed and pertinent information extracted onto a data capture sheet. The data was stored on an Excel datasheet. Mean duration between first surgery and redo was 8. Presenting features at redo surgery were congestive cardiac failure 27 , chest pain 11 and palpitations Mean preoperative Ejection Fraction was Thirty-two patients had tricuspid regurgitation.

The most commonly used valve was the On-X. Mean presenting INR was 1. Two patients died postoperatively. Twelve patients Physiologic changes during pregnancy can deteriorate or improve patients' hemodynamic status in the setting of valvular heart disease. There are sparse data regarding the effect of pregnancy on valve hemodynamics in normal pregnant women with known valvular heart disease.

In a prospective study from July to January , a total of 52 normal pregnant women who had mitral stenosis, aortic stenosis, or a history of mitral valve or aortic valve replacements were assessed. All patients underwent echocardiographic examinations and hemodynamic parameters were measured for both the mitral valve and aortic valve at first, second, and third trimesters. Although most hemodynamic parameters i. The ratio of changes between trimesters for valve area and dimensionless velocity index were comparable.

No clinical decompensations were observed except for 3 and 7 cases of deterioration to functional class II at second and third trimesters, respectively. In conclusion, during a full-term and uncomplicated pregnancy, mitral and aortic valve gradients increase without significant changes in valve area that are more marked between the second and first trimester than between the third and second trimester.

Aortic valve insufficiency in the teenager and young adult: the role of prosthetic valve replacement. The contents of this article were presented in the session "Aortic insufficiency in the teenager" at the congenital parallel symposium of the Society of Thoracic Surgeons STS annual meeting. The accompanying articles detail the approaches of aortic valve repair and the Ross procedure. For many young patients requiring aortic valve surgery, either aortic valve repair or a Ross procedure provides a good option.

The advantages include avoidance of anticoagulation and potential for growth. In other patients, a prosthetic valve is an appropriate alternative. This article discusses the current state of knowledge regarding mechanical and bioprosthetic valve prostheses and their specific advantages relative to valve repair or a Ross procedure. In current practice, young patients requiring aortic valve surgery frequently undergo valve replacement with a prosthetic valve.

In the future, the balance among these options may be altered by design improvements in prosthetic valves , alternatives to warfarin, the development of new patch materials for valve repair, and techniques to avoid Ross autograft failure. Multifunctional four-port directional control valve constructed from logic valves. Their widespread use in many machines and devices causes a continuing interest in the development of their design by both the scientific centers and the industry.

The valve design methodology takes into account the need to seek solutions that minimize flow resistance through the valve. For this purpose, the flow paths are prepared by means of CAD software and pressure-flow curves are determined as a result of CFD analysis. The obtained curves are compared with the curves available in the catalogs of spool type directional control valves.

The new solution allows to replace the whole family of spool type four-port directional control valves by one valve built of logic valves. In addition, the innovative directional control valve provides leak-proof shutting the flow paths off and also it can control flow rate and even pressure of working liquid. A prototype of the valve designed by the presented method has been made and tested on the test bench.

The results quoted in the paper confirm that the developed logic type directional control valve is able to meet all designed connection configurations, and the obtained pressure-flow curves show very good conformity with the results of CFD analysis. The study aim was to assess, in vitro, the hemodynamic modifications produced by transcatheter valves in the Valsalva sinuses, by mean of phase-resolved particle image velocimetry PIV measurements. Flow measurements were performed on a glass mock aortic root that included three polymeric valve leaflets, before and after the implantation of a Medtronic Core Valve device and of an Edwards SAPIEN valve.

All experiments were carried out in a hydro-mechanical cardiovascular pulse duplicator system Vivitro Superpump System SP that reproduced physiologically equivalent pressures and flow rates conforming to the requirements of the standard ISO The flow dynamics, before and after implantation of the two prosthetic devices, was characterized on the basis of phase-resolved velocity field and viscous shear rate measurements.

Direct comparison indicated that both transcatheter valves determined a significant variation of flow during the early stages of valve opening and during valve closure. In general, the presence of the two valve implants significantly reduced the flow activity in the Valsalva sinuses, promoting regions of stagnation at their base.

The reduction in flow in the Valsalva sinuses could be associated with the higher incidence of ischemic events reported after transcatheter heart valve implantation. The incidence of aortic regurgitation AR after transcatheter aortic valve replacement TAVR in a self-expanding and a balloon-expandable system is controversial.

Baseline, procedural, and postprocedural inhospital outcomes were compared. A multivariate logistic regression analysis was completed to evaluate for correlates of the primary end point. The secondary end points included the change in severity of AR at day and 1-year follow-up.

There were significant differences in the rates of intraprocedural balloon postdilation with the CV There were no significant differences in inhospital safety outcomes between the 2 groups. In conclusion, the incidence of post-TAVR AR is similar between the CV and the XT valve when performed by experienced operators using optimal intraprocedural strategies, as deemed appropriate, to mitigate the severity of AR.

This study aimed to evaluate the safety and feasibility of transaortic mitral pannus removal TMPR. The median time interval from the previous surgery was 14 years. TMPR was performed in 2 patients through a normal aortic valve. Prophylactic TMPR was performed in 23 patients. There were no early deaths. Concomitant operations included 22 tricuspid valve surgeries 13 replacements, 15 repairs and 32 aortic valve replacements 24 repeats, 8 primary. To report and compare the results of trabeculectomy with mitomycin C MMC and Ahmed valve implantation in the management of uveitic glaucoma.

The records of 41 eyes of 29 patients who underwent trabeculectomy with MMC or Ahmed valve implantation for uveitic glaucoma were retrospectively reviewed. Seventeen eyes underwent trabeculectomy with MMC, and 24 eyes underwent Ahmed valve implantation. Outcomes included postoperative intraocular pressure IOP , percent reduction from preoperative IOP, postoperative number of medications, time to failure, and complications.

Cumulative success at 1 year was Mean time to failure was 8. Complications in both groups were typically rare and self-limited, with recurrent inflammation being most common. Although both trabeculectomy with MMC and Ahmed valve implantation are reasonable surgical options in the management of uncontrolled uveitic glaucoma, Ahmed valve implantation was associated with higher cumulative success rate at 1 year and a longer mean time to failure. First report on a human percutaneous transluminal implantation of a self-expanding valve prosthesis for interventional treatment of aortic valve stenosis.

Percutaneous aortic valve replacement is a new technology for the treatment of patients with significant aortic valve stenosis. We present the first report on a human implantation of a self-expanding aortic valve prosthesis, which is composed of three bovine pericardial leaflets inserted within a self-expanding nitinol stent. The year-old woman presented with severe symptomatic aortic valve stenosis mean transvalvular gradient of 45 mmHg; valve area of 0.

Surgical valve replacement had been declined for the patient because of comorbidities, including previous bypass surgery. A retrograde approach via the common iliac artery was used for valve deployment. The contralateral femoral vessels were used for a temporary extracorporal circulation, unloading the left ventricle during the actual stent expansion.

Clinical, hemodynamic, and echocardiographic outcomes were assessed serially during the procedure. Clinical and echocardiographic follow-up at day 1, 2, and 14 post procedure was performed to evaluate the short-term outcome. The prosthesis was successfully deployed within the native aortic valve , with accurate and stable positioning and with no impairment of the coronary artery or vein graft blood flow.

The clinical status has then significantly improved. These results remained unchanged up to the day 14 follow-up. This case report demonstrates a successful percutaneous implantation of a self-expanding aortic valve prosthesis with remarkable functional and clinical improvements in the acute and short-term outcome. Copyright c Wiley-Liss, Inc. Small sodium valve design and operating experience.

Various test programs have been, and are being, conducted to verify the performance and integrity of the FFTF valves , and to uncover any potential problems so that they can be corrected before the valves are placed in service in FFTF. The principal small sodium valve designs being utilized in current U. The standards and requirements to which the valves are being designed and fabricated, the valve designs in current use, valve operators, test and operating experience, and future valve development plans are summarized.

Proving test on the reliability for nuclear valves. Since valves are the most common components, they could be the most frequent causes of troubles in nuclear power plants. This proving test, therefore, has an important meaning to examine and verify the reliability of various valves under simulating conditions of abnormal and transient operations of the nuclear power plant.

The test was performed mainly for the various types and pressure ratings of valves which were used in the primary and secondary systems in BWR and PWR nuclear power plants and which had major operating or safety related functions in those nuclear power plants. The results of the proving test, confirmed for more than four years, showed relatively favourable performance of the tested valves.

It is concluded that performances of valves including operability, seat sealing and structural integrity were proved under the thermal cycling, vibration and pipe reaction load conditions. Operating functions during and after accident such as loss of coolant accident were satisfactory. From these results, it was considered that the purpose of this proving test was satisfactorily fulfilled. Several data accumulated by the test would be useful to get better reliability if it was evaluated with the actually experienced data of valves in the nuclear power plants.

Nogami, K. Cavitation guide for control valves. This guide teaches the basic fundamentals of cavitation to provide the reader with an understanding of what causes cavitation, when it occurs, and the potential problems cavitation can cause to a valve and piping system. The guide provides a method for predicting the cavitation intensity of control valves , and how the effect of cavitation on a system will vary with valve type, valve function, valve size, operating pressure, duration of operation and details of the piping installation.

The guide defines six cavitation limits identifying cavitation intensities ranging from inception to the maximum intensity possible. The intensity of the cavitation at each limit Is described, including a brief discussion of how each level of cavitation influences the valve and system. Examples are included to demonstrate how to apply the method, including making both size and pressure scale effects corrections.

Methods of controlling cavitation are discussed providing information on various techniques which can be used to design a new system or modify an existing one so it can operate at a desired level of cavitation. Aortic valve bypass.

In aortic valve bypass AVB a valve -containing conduit is connecting the apex of the left ventricle to the descending aorta. Candidates are patients with symptomatic aortic valve stenosis rejected for conventional aortic valve replacement AVR or transcatheter aortic valve implantation TAVI. Acoustic valve leak detection in nuclear plants. Internal valve leakage is a hidden energy loss and can cause or prolong a forced outage.

Recent advances in acoustic detection of internal valve leakage have reduced piping system maintenance costs, unnecessary downtime, and energy waste. Extremely short payback periods have been reported by plants applying this technology to preventive maintenance, troubleshooting, energy conservation and outage planning. Sensors temporarily attached to the outside of valves and connected to the instruments detect ultrasonic acoustic emissions which are characteristic of internal valve leakage.

Since the sensors are attached to the outside of the valves , the time and expense of dismantling the valves or removing them from the systems are eliminated. This paper describes the instrumentation and specific applications to nuclear plant valves , including independent verification of initial findings. Guidelines for potential users, including instrumentation selection, training requirements, application planning, and the choice of in-house versus contract services are discussed.

Periodontitis is an infectious disease that affects the support tissue of the teeth and it is associated with different systemic diseases, including cardiovascular disease. Microbiological studies facilitate the detection of microorganisms from subgingival and cardiovascular samples. To describe the cultivable periodontal microbiota and the presence of microorganisms in heart valves from patients undergoing valve replacement surgery in a clinic in Cali.

We analyzed 30 subgingival and valvular tissue samples by means of two-phase culture medium, supplemented blood agar and trypticase soy agar with antibiotics. Conventional PCR was performed on samples of valve tissue. Conventional PCR did not return positive results for oral pathogens and bacterial DNA was detected only in two samples.

Periodontal microbiota of patients undergoing surgery for heart valve replacement consisted of species of Gram-negative bacteria that have been associated with infections in extraoral tissues. However, there is no evidence of the presence of periodontal pathogens in valve tissue, because even though there were valve and subgingival samples positive for Gram-negative enteric bacilli, it is not possible to maintain they corresponded to the same phylogenetic origin. Early Outcomes of Sutureless Aortic Valves.

The potential advantages of sutureless aortic prostheses include reducing cross-clamping and cardiopulmonary bypass CPB time and facilitating minimally invasive surgery and complex cardiac interventions, while maintaining satisfactory hemodynamic outcomes and low rates of paravalvular leakage.

The current study reports our single-center experience regarding the early outcomes of sutureless aortic valve implantation. Methods: Between October and June , 65 patients scheduled for surgical valve replacement with symptomatic aortic valve disease and New York Heart Association function of class II or higher were included to this study.

Results: The mean age of the patients was Forty-four patients The average preoperative left ventricular ejection fraction was The CPB time was The intubation time was 8. The mean quantity of drainage from chest tubes was The hospital mortality rate was 3. A total of five patients 7. The mean follow-up time was Conclusion: In the last few years, several models of valvular sutureless bioprostheses have been developed.

The present study evaluating the single-center early outcomes of sutureless aortic valve implantation presents the results of an innovative surgical technique, finding that it resulted in appropriate hemodynamic conditions with acceptable ischemic time. In elderly high-risk surgical patients, sutureless aortic valve replacement AVR should be an alternative to standard AVR.

Between October and June , 65 patients scheduled for surgical valve replacement with symptomatic aortic valve disease and New York Heart Association function of class II or higher were included to this study. The mean age of the patients was In the last few years, several models of valvular sutureless bioprostheses have been developed. Steam turbine power plant having improved testing method and system for turbine inlet valves associated with downstream inlet valves preferably having feedforward position managed control.

A throttle valve test system for a large steam turbine functions in a turbine control system to provide throttle and governor valve test operations. The control system operates with a valve management capability to provide for pre-test governor valve mode transfer when desired, and it automatically generates feedforward valve position demand signals during and after valve tests to satisfy test and load control requirements and to provide smooth transition from valve test status to normal single or sequential governor valve operation.

A digital computer is included in the control system to provide control and test functions in the generation of the valve position demand signals. Transcatheter aortic valve replacement. Transcatheter aortic valve replacement TAVR is surgery to replace the aortic valve. Minimally invasive aortic valve replacement. In this descriptive prospective study, we evaluate the outcomes of surgery in 98 patients who were scheduled to undergo minimally invasive aortic valve replacement.

These patients were compared with a group of 50 patients who underwent scheduled aortic valve replacement through a full sternotomy The aortic cross-clamp and perfusion times were significantly different across all groups P replacement The "extended mini-aortic valve replacement" operation, on the other hand, is a risky procedure that should Magnetically operated check valve.

A magnetically operated check valve is disclosed. The valve is comprised of a valve body and a movable poppet disposed therein. A magnet attracts the poppet to hold the valve shut until the force of fluid flow through the valve overcomes the magnetic attraction and moves the poppet to an unseated, open position. The poppet and magnet are configured and disposed to trap a magnetically attracted particulate and prevent it from flowing to a valve seating region.

Pulmonary valve disruption in patients with tetralogy of Fallot and congenital pulmonary stenosis often results in pulmonary insufficiency, right ventricular dilation, and tricuspid valve regurgitation. Management of functional tricuspid regurgitation at the time of subsequent pulmonary valve replacement remains controversial.

Our aims were to 1 analyze tricuspid valve function after pulmonary valve replacement through midterm follow-up and 2 determine the benefits, if any, of concomitant tricuspid annuloplasty. Thirty-five patients with tetralogy of Fallot or congenital pulmonary stenosis were analyzed. All patients had been palliated in childhood by disrupting the pulmonary valve , and all patients had at least moderate tricuspid valve regurgitation at the time of subsequent pulmonary valve replacement. Preoperative and serial postoperative echocardiograms were analyzed.

Pulmonary and tricuspid regurgitation, along with right ventricular dilation and dysfunction were scored as 0 none , 1 mild , 2 moderate , and 3 severe. Right ventricular volume and area were also calculated. Comparisons were made between patients who underwent pulmonary valve replacement alone and those who underwent concomitant tricuspid valve annuloplasty. At 1 month after pulmonary valve replacement, there were significant reductions in pulmonary valve regurgitation mean 3 vs 0.

However, at latest follow-up mean 7. In patients with at least moderate tricuspid valve regurgitation, significant improvement in tricuspid valve function and right ventricular size occurs in the first. What Is Heart Valve Surgery? Most valve replacements involve the aortic Tricuspid valve and mitral valves. The aortic valve separates This is called incompetence, insufficiency or regurgitation.

What Is Heart Valve Disease? Biological valves are made from pig, cow, or human Ministernotomy: A preliminary experience in heart valve surgery. The last decade of the 20th century brought up a significant development in the field of minimally invasive approaches to the valvular heart surgery. Potential benefits of this method are: good esthetic appearance, reduced pain, reduction of postoperative hemorrhage and incidence of surgical site infection, shorter postoperative intensive care units ICU period and overall in-hospital period.

Partial upper median sternotomy currently presents as a state-of-the art method for minimally invasive surgery of cardiac valves. The aim of this study was to report on initial experience in application of this surgical method in the surgery of mitral and aortic valves.

The study was designed and conducted in a prospective manner and included all the patients who underwent minimally invasive cardiac valve surgery through the partial upper median sternotomy during the period November - August We analyzed the data on mean age of patients, mean extubation time, mean postoperative drainage, mean duration of hospital stay, as well as on occurance of postoperative complications postoperative bleeding, surgical site infection and cerebrovascular insult. During the observed period, in the Institute for Cardiovascular Diseases of Vojvodina, Clinic for Cardiovascular Surgery, 17 ministernotomies were performed, with 14 aortic valve replacements Mean age of the patients was Mean extubation time was Mean duration of hospital stay was Mean postoperative drainage was Postoperative complications included : bleeding 5.

One patient 5. Partial upper median sternotomy represents. Partial upper median stemotomy currently presents as a state-of-the art method for minimally invasive surgery of cardiac valves. The study was designed and conducted in a prospective manner and included all the patients who underwent minimally invasive cardiac valve surgery through the partial upper median stemotomy during the period November - August Partial upper median sternotomy represents the optimal surgical method for the interventions on the.

Turbulence downstream of subcoronary stentless and stented aortic valves. Regions of turbulence downstream of bioprosthetic heart valves may cause damage to blood components, vessel wall as well as to aortic valve leaflets. Stentless aortic heart valves are known to posses several hemodynamic benefits such as larger effective orifice areas, lower aortic transvalvular pressure difference and faster left ventricular mass regression compared with their stented counterpart.

Whether this is reflected by diminished turbulence formation, remains to be shown. We implanted either stented pericardial valve prostheses Mitroflow , stentless valve prostheses Solo or Toronto SPV in pigs or they preserved their native valves. Following surgery, blood velocity was measured in the cross sectional area downstream of the valves using 10MHz ultrasonic probes connected to a dedicated pulsed Doppler equipment.

We found no difference in maximum RNS measurements between any of the investigated valve groups. We, thus, found no advantages for the stentless aortic valves compared with stented prosthesis in terms of lower maximum or mean RNS values. Native valves have a significantly lower mean RNS value than all investigated bioprostheses. Butterfly valve torque prediction methodology.

This paper presents the methodology that will be used by utilities to calculate the dynamic torque requirements for butterfly valves. The total dynamic torque at any disc position is the sum of the hydrodynamic torque, bearing torque which is induced by the hydrodynamic force , as well as other small torque components such as packing torque. The hydrodynamic torque on the valve disc, caused by the fluid flow through the valve , depends on the disc angle, flow velocity, upstream flow disturbances, disc shape, and the disc aspect ratio.

The butterfly valve model provides sets of nondimensional flow and torque coefficients that can be used to predict flow rate and hydrodynamic torque throughout the disc stroke and to calculate the required actuation torque and the maximum transmitted torque throughout the opening and closing stroke. The scope of the model includes symmetric and nonsymmetric discs of different shapes and aspects ratios in compressible and incompressible fluid applications under both choked and nonchoked flow conditions.

The model features were validated against test data from a comprehensive flowloop and in situ test program. These tests were designed to systematically address the effect of the following parameters on the required torque: valve size, disc shapes and disc aspect ratios, upstream elbow orientation and its proximity, and flow conditions.

The applicability of the nondimensional coefficients to valves of different sizes was validated by performing tests on in. The butterfly valve model torque predictions were found to bound test data from the flow-loop and in situ testing, as shown in the examples provided in this paper. Selective Laser Melting SLM was utilized to fabricate a liquid hydrogen valve housing typical of those found in rocket engines and main propulsion systems. The SLM process allowed for a valve geometry that would be difficult, if not impossible to fabricate by traditional means.

Several valve bodies were built by different SLM suppliers and assembled with valve internals. Sabine Welsch Fr. Olivia Condac. Frank Louwen Dr. Susanne Feidicker Dr. Wiebke Schaarschmidt Dr. Lena Raddatz Dr. Ammar Al Naimi Dr. Akos Herzeg Dr. Roman Allert Dr. Anna Elisabeth Hentrich Dr. Lisa Holetzke Dr. Kyra Fischer Thea Hug Dr. Lukas Jennewein Dr. Ulrikke Kielland-Kaisen Dr. Melika Mikic Dr. Annemarie Neuhoff Dr. Marlene Irani Dr. Juping Yuan Dr. Silvia Oddo-Sommerfeld M. Miriam Bieber M.

Sarah Sommerlad M. Monat 2. Monat 3. Monat 4. Monat 5. Monat 6. Monat 7. Monat 8. Monat 9. Monat Lehre Vorlesung Praktikum Tipps Famulatur. KollegInnen Veranstaltungen. Stefan Zeuzem. Lehre Famulaturen Pflichtveranstaltungen Promotionsthemen Vorlesungen.

Lehre und Weiterbildung Lehre Weiterbildung. Patientenprobe Etiketten Probentransport Probenaufbewahrung. Spenden Unsere Spender. Pflege Pflege in der Kinder- und Jugendmedizin. Therapien Tiefe Hirnstimulation Zungenschrittmacher. Basant K. Misra Professor Dr. Nelson M. Oyesiku Professor Dr.

Hee-Won Jung Professor Dr. Paolo Cappabianca Professor Dr. Necmettin Pamir Professor Dr. Albert L. Rhoton, Jr. Professor Dr. Madjid Samii. Thomas Westermaier Prof. Jose Alberto Landeiro Nelson M. Maximilian Ruge Professor Dr.

WOODBRIDGE FAVORITES OFF-TRACK BETTING LOCATIONS

We conclude that heterozygote advantage and local effects may be more common and evolutionarily significant than is generally appreciated. Mitochondrial genomes of praying mantises Dictyoptera, Mantodea : rearrangement , duplication, and reassignment of tRNA genes. Insect mitochondrial genomes mitogenomes contain a conserved set of 37 genes for an extensive diversity of lineages. Previously reported dictyopteran mitogenomes share this conserved mitochondrial gene arrangement, although surprisingly little is known about the mitogenome of Mantodea.

We sequenced eight mantodean mitogenomes including the first representatives of two families: Hymenopodidae and Liturgusidae. Only two of these genomes retain the typical insect gene arrangement. In three Liturgusidae species, the trnM genes have translocated. Four species of mantis Creobroter gemmata, Mantis religiosa, Statilia sp.

These extra trnR and trnW in Statilia sp. Interestingly, the extra trnW is converted from trnR by the process of point mutation at anticodon, which is the first case of tRNA reassignment for an insect. Furthermore, no significant differences were observed amongst mantodean mitogenomes with variable copies of tRNA according to comparative analysis of codon usage. Combined with phylogenetic analysis, the characteristics of tRNA only possess limited phylogenetic information in this research.

Nevertheless, these features of gene rearrangement , duplication, and reassignment provide valuable information toward understanding mitogenome evolution in insects. Rearranged anaplastic lymphoma kinase ALK gene in adult-onset papillary thyroid cancer amongst atomic bomb survivors. In contrast, the frequency of PTC cases with point mutations mainly BRAF VE was significantly lower in patients with relatively higher radiation exposure than those with lower radiation exposure.

However, in ABS with PTC, the relationship between the presence of the anaplastic lymphoma kinase ALK gene fused with other gene partners and radiation exposure has received little study. In contrast, the frequency of PTC cases with point mutations mainly BRAFVE was significantly lower in patients with relatively higher radiation exposure than those with lower radiation exposure.

Evolution of the mitochondrial genome in snakes: Gene rearrangements and phylogenetic relationships. Background Snakes as a major reptile group display a variety of morphological characteristics pertaining to their diverse behaviours. Despite abundant analyses of morphological characters, molecular studies using mitochondrial and nuclear genes are limited.

As a result, the phylogeny of snakes remains controversial. Previous studies on mitochondrial genomes of snakes have demonstrated duplication of the control region and translocation of trnL to be two notable features of the alethinophidian all serpents except blindsnakes and threadsnakes mtDNAs.

Our purpose is to further investigate the gene organizations, evolution of the snake mitochondrial genome, and phylogenetic relationships among several major snake families. Results The mitochondrial genomes were sequenced for four taxa representing four different families, and each had a different gene arrangement. Comparative analyses with other snake mitochondrial genomes allowed us to summarize six types of mitochondrial gene arrangement in snakes.

Phylogenetic reconstruction with commonly used methods of phylogenetic inference BI, ML, MP, NJ arrived at a similar topology, which was used to reconstruct the evolution of mitochondrial gene arrangements in snakes. Conclusion The phylogenetic relationships among the major families of snakes are in accordance with the mitochondrial genomes in terms of gene arrangements.

The gene arrangement in Ramphotyphlops braminus mtDNA is inferred to be ancestral for snakes. After the divergence of the early Ramphotyphlops lineage, three types of rearrangements occurred. The chloroplast genome CPG of Pinus massoniana belonging to the genus Pinus Pinaceae , which is a primary source of turpentine, was sequenced and analyzed in terms of gene rearrangements , ndh genes loss, and the contraction and expansion of short inverted repeats IRs.

Comparisons with related species revealed an inversion 21, bp in the LSC region; P. A pair of short IRs was found instead of large IRs, and size variations among pine species were observed, which resulted from short insertions or deletions and non-synchronized variations between "IRa" and "IRb". The results of phylogenetic analyses based on whole CPG sequences of 16 conifers indicated that the whole CPG sequences could be used as a powerful tool in phylogenetic analyses. Aml1 gene rearrangements and mutations in radiation-associated acute myeloid leukemia and myelodysplastic syndromes.

Of these patients, 24 had experienced radiation exposure due to the Chernobyl accident, and 29 were non-irradiated spontaneous AML cases and served as controls. Our results suggest that AML1 gene translocations are infrequent in radiation-induced leukemogenesis but are consistent with the idea that radiation may contribute to the development of MDS through AML1 gene mutation. Chromosomal rearrangements and gene flow over time in an inter-specific hybrid zone of the Sorex araneus group.

Most hybrid zones have existed for hundreds or thousands of years but have generally been observed for only a short time period. Studies extending over periods long enough to track evolutionary changes in the zones or assess the ultimate outcome of hybridization are scarce. Here, we describe the evolution over time of the level of genetic isolation between two karyotypically different species of shrews Sorex araneus and Sorex antinorii at a hybrid zone located in the Swiss Alps.

We first evaluated hybrid zone movement by contrasting patterns of gene flow and changes in cline parameters centre and width using 24 microsatellite loci, between two periods separated by 10 years apart. Additionally, we tested the role of chromosomal rearrangements on gene flow by analysing microsatellite loci located on both rearranged and common chromosomes to both species.

We did not detect any movement of the hybrid zone during the period analysed, suggesting that the zone is a typical tension zone. However, the gene flow was significantly lower among the rearranged than the common chromosomes for the second period, whereas the difference was only marginally significant for the first period. This further supports the role of chromosomal rearrangements on gene flow between these taxa.

Chromosome rearrangements induce both variegated and reduced, uniform expression of heterochromatic genes in a development-specific manner. In Drosophila melanogaster, chromosome rearrangements that juxtapose euchromatin and heterochromatin can result in position effect variegation PEV , the variable expression of heterochromatic and euchromatic genes in the vicinity of the novel breakpoint.

We examined PEV of the heterochromatic light lt and concertina cta genes in order to investigate potential tissue or developmental differences in chromosome structure that might be informative for comparing the mechanisms of PEV of heterochromatic and euchromatic genes. We employed tissue pigmentation and in situ hybridization to RNA to assess expression of lt in individual cells of multiple tissues during development.

Variegation of lt was induced in the adult eye, larval salivary glands and larval Malpighian tubules for each of three different chromosome rearrangements. The relative severity of the effect in these tissues was not tissue-specific but rather was characteristic of each rearrangement.

Surprisingly, larval imaginal discs did not exhibit variegated lt expression. Instead, a uniform reduction of the lt transcript was observed, which correlated in magnitude with the degree of variegation. The same results were obtained for cta expression.

These two distinct effects of rearrangements on heterochromatic gene expression correlated with the developmental stage of the tissue. These results have implications for models of heterochromatin formation and the nuclear organization of chromosomes during development and differentiation. A balanced t 5;17 p15;q in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes.

Background Chondroblastoma is a benign cartilaginous tumour of bone that predominantly affects the epiphysis of long bones in young males. No recurrent chromosomal re-arrangements have so far been observed.

Candidate region re-arrangement and candidate gene expression were subsequently investigated by interphase FISH and immunohistochemistry in another 14 cases. Results A balanced t 5;17 p15;q was identified. In the index case, interphase FISH showed that the translocation was present only in mononucleated cells and was absent in the characteristic multinucleated giant cells. The t 5;17 translocation was not observed in the other cases studied.

Expression of the protein was found in all cases tested. Similar expression was found for the sex steroid signalling-related molecules oestrogen receptor alpha and aromatase, while androgen receptors were only found in isolated cells in a few cases. All other cases showed variable levels of CA10 expression, with low expression in three cases. Conclusion We report a novel t 5;17 p15;q translocation in chondroblastoma without involvement of any of the two chromosomal regions in other cases studied.

Our results indicate that the characteristic multinucleated giant cells in chondroblastoma do not have the same clonal origin as the mononuclear population, as they do not harbour the same translocation. We therefore hypothesise that they might be either reactive or originate from a distinct. Anaplastic lymphoma kinase ALK gene rearrangements in radiation-related human papillary thyroid carcinoma after the Chernobyl accident.

Childhood radiation exposure has been associated with increased papillary thyroid carcinoma PTC risk. Among the 77 tumours from exposed persons, we identified 7 ALK rearrangements and none in the unexposed group. Odds ratios increased significantly in a dose-dependent manner up to 6. In total, 27 cases carried point mutations of BRAF or RAS genes , yet logistic regression analysis failed to identify significant dose association.

Our findings further support the hypothesis that gene rearrangements , but not oncogenic driver mutations, are associated with ionizing radiation-related tumour risk. IHC may represent an effective method for ALK-screening in PTCs with known radiation aetiology, which is of clinical value since oncogenic ALK activation might represent a valuable target for small molecule inhibitors. Among the mutations described in non-small cell lung carcinoma is a rearrangement resulting from an inversion within chromosome 2p leading to the formation of a fusion gene , echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase EML4-ALK.

However, molecular methods are not readily available in all pathology laboratories. IHC shows promise as a screening tool. Analysis of genomic rearrangements , horizontal gene transfer and role of plasmids in the evolution of industrial important Thermus species. Bacteria of genus Thermus inhabit both man-made and natural thermal environments. Several Thermus species have shown biotechnological potential such as reduction of heavy metals which is essential for eradication of heavy metal pollution; removing of organic contaminants in water; opening clogged pipes, controlling global warming among many others.

Enzymes from thermophilic bacteria have exhibited higher activity and stability than synthetic or enzymes from mesophilic organisms. Using Meiothermus silvanus DSM as a reference genome, high level of coordinated rearrangements has been observed in extremely thermophilic Thermus that may imply existence of yet unknown evolutionary forces controlling adaptive re-organization of whole genomes of thermo-extremophiles.

However, no remarkable differences were observed across species on distribution of functionally related genes on the chromosome suggesting constraints imposed by metabolic networks. The metabolic network exhibit evolutionary pressures similar to levels of rearrangements as measured by the cross-clustering index. Using stratigraphic analysis of donor-recipient, intensive gene exchanges were observed from Meiothermus species and some unknown sources to Thermus species confirming a well established DNA uptake mechanism as previously proposed.

Global genome rearrangements were found to play an important role in the evolution of Thermus bacteria at both genomic and metabolic network levels. Relatively higher level of rearrangements was observed in extremely thermophilic Thermus strains in comparison to the thermo-tolerant Thermus scotoductus. Rearrangements did not significantly disrupt operons and functionally related genes.

Thermus species appeared to have a developed capability for acquiring DNA through horizontal gene transfer as shown by the donor-recipient stratigraphic analysis. Cyclic stretch-induced the cytoskeleton rearrangement and gene expression of cytoskeletal regulators in human periodontal ligament cells. This study aimed to explore the mechanism of the stretch-induced cell realignment and cytoskeletal rearrangement by identifying several mechanoresponsive genes related to cytoskeletal regulators in human PDL cells.

Western blot was applied to identify the protein expression level of several cytoskeletal regulators encoded by these differentially expressed genes. The confocal fluorescent staining results confirmed that stretch-induced realignment of cells and rearrangement of microfilaments. The present study confirmed the cyclic stretch-induced cellular realignment and rearrangement of microfilaments in the human PDL cells and indicated several force-sensitive genes with regard to cytoskeletal regulators.

Complete mitochondrial genomes of Trisidos kiyoni and Potiarca pilula: Varied mitochondrial genome size and highly rearranged gene order in Arcidae. We present the complete mitochondrial genomes mitogenomes of Trisidos kiyoni and Potiarca pilula, both important species from the family Arcidae Arcoida: Arcacea.

The mitogenomes of Arcidae species are exceptional for their extraordinarily large and variable sizes and substantial gene rearrangements. The mitogenome of T. The compact mitogenomes are weakly associated with gene number and primarily reflect shrinkage of the non-coding regions.

The varied size in Arcidae mitogenomes reflect a dynamic history of expansion. This analysis imply that the complicated gene rearrangement in mitochondrial genome could be considered as one of key characters in inferring higher-level phylogenetic relationship of Arcidae. Crizotinib treatment significantly prolongs progression-free survival, increases response rates, and improves the quality of life in patients with ALK-positive non-small-cell lung cancer.

Droplet Digital PCR ddPCR , a recently developed technique with high sensitivity and specificity, was used in this study to evaluate the association between the abundance of ALK rearrangements and crizotinib effectiveness. FFPE tissues were obtained from consecutive patients with lung adenocarcinoma. The results revealed that 14 Two of them responded well to crizotinib after unsuccessful chemotherapy.

Published by Elsevier Inc. Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma. Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, comprising childhood and adult tumours encompassing all major histological subtypes.

These findings may inform patient selection in future trials of IGF1R inhibitors in osteosarcoma. This process operates recurrently at discrete genomic regions and generates driver mutations. Lastly, it may represent an age-independent mutational mechanism that contributes to the development of osteosarcoma in children and adults alike.

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL- rearranged leukemias. Six cases harbored NPM1 mutations, with each case lacking common cytogenetic abnormalities. As dysregulated homeobox gene expression is also a feature of MLL- rearranged leukemia, the gene expression signatures of NPM1-mutated and MLL- rearranged leukemias were compared.

Consugar, Mark B. PKD1 is located in an intrachromosomally duplicated region. To rapidly identify large rearrangements , a multiplex ligation-dependent probe amplification assay was developed employing base-pair differences between PKD1 and the six pseudogenes to generate PKD1-specific probes.

Characterization of a family found to be mosaic for a PKD1 deletion is discussed here to illustrate family risk and donor selection considerations. Heterokaryon vegetative incompatibility, governing the fusion of somatic hyphal filaments to form stable heterokaryons, is of interest because of its widespread occurrence in fungi and its bearing on cellular recognition. Conventional investigations of the genetic basis of heterokaryon incompatibility in N.

This difficulty is overcome by using duplications partial diploids that are unlikely to contain more than one het locus. A phenotypically expressed incompatibility reaction occurs when unlike het alleles are present within the same somatic nucleus, and this parallels the heterokaryon incompatibility reaction that occurs when unlike alleles in different haploid nuclei are introduced into the same somatic hypha by mycelial fusion.

This was demonstrated for three loci which had previously been established by conventional heterokaryon tests—het-e, het-c and mt. These were each obtained in duplications as recombinant meiotic segregants from crosses heterozygous for duplication-generating chromosome rearrangements. The particular method of producing the duplications is irrelevant so long as the incompatibility alleles are heterozygous. In laboratory strains both loci are represented simply by two alleles.

Analysis of het-c is more complicated in some wild strains, where differences have been demonstrated at one or more additional het loci within the duplication used and multiple allelism is also possible. In this case, a deletion encompassing the last intron and part of exon 15 of MYB, including the binding site of ERG-1, a transcription factor that may downregulate MYB, and the exon 15 splice site, was detected.

Establishment and characterization of scleroderma fibroblast clonal cell lines by introduction of the hTERT gene. Abstract Lack of an adequate experimental model has hindered the ability to fully understand scleroderma SSc pathogenesis. Current SSc research is based on the study of cultured fibroblasts from skin biopsies. In depth characterization of the SSc fibroblast phenotype is hindered by the limited lifespan and heterogeneity of these cells.

The goal of this study was to isolate high collagen-producing fibroblasts from SSc biopsies and extend their lifespan with hTERT immortalization to enable characterization of their phenotype. Infected colonies were isolated, cultured into clonal cell lines and analysed with respect to profibrotic gene expression. Protein levels were assessed by Western blot. A subset of the SSc clones showed elevated expression levels of collagen I, connective tissue growth factor and thrombospondin 1 mRNA, while expression of other genes was not significantly changed.

Elevated expression of collagen I protein and mRNA was correlative with elevated expression of connective tissue growth factor. A portion of SSc clones expressed several profibrotic genes. This study demonstrates that select characteristics of the SSc phenotype are expressed in a subset of activated fibroblasts in culture. The clonal SSc cell lines may present a new and useful model to investigate the mechanisms involved in SSc fibrosis.

Lack of an adequate experimental model has hindered the ability to fully understand scleroderma SSc pathogenesis. Comparative linkage mapping of genes on sheep chromosome 3 provides evidence of chromosomal rearrangements in the evolution of the Bovidae. The order and genetic distances between loci on OAR 3 are similar to those on cattle Bos taurus chromosome 5, as expected from their close evolutionary relationship.

The OAR 3 linkage map shows conserved synteny with human chromosome 12, but there are at least two rearrangements in gene order between the species. We use full mitochondrial genomes to test the robustness of the phylogeny of the Octocorallia, to determine the evolutionary pathway for the five known mitochondrial gene rearrangements in octocorals, and to test the suitability of using mitochondrial genomes for higher taxonomic-level phylogenetic reconstructions.

Our phylogeny supports three major divisions within the Octocorallia and show that Paragorgiidae is paraphyletic, with Sibogagorgia forming a sister branch to the Coralliidae. Furthermore, Sibogagorgia cauliflora has what is presumed to be the ancestral gene order in octocorals, but the presence of a pair of inverted repeat sequences suggest that this gene order was not conserved but rather evolved back to this apparent ancestral state.

Based on this we recommend the resurrection of the family Sibogagorgiidae to fix the paraphyly of the Paragorgiidae. This is the first study to show that in the Octocorallia, mitochondrial gene orders have evolved back to an ancestral state after going through a gene rearrangement , with at least one of the gene orders evolving independently in different lineages.

A number of studies have used gene boundaries to determine the type of mitochondrial gene arrangement present. However, our findings suggest that this method known as gene junction screening may miss evolutionary reversals. Additionally, substitution saturation analysis demonstrates that while whole mitochondrial genomes can be used effectively for phylogenetic analyses within Octocorallia, their utility at higher taxonomic levels within Cnidaria is inadequate.

Therefore for phylogenetic reconstruction at taxonomic levels higher than subclass within the Cnidaria, nuclear genes will be required, even when whole mitochondrial genomes are available. Octocoral mitochondrial genomes provide insights into the phylogenetic history of gene order rearrangements , order reversals, and cnidarian phylogenetics. Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not MLL gene. The translocations included t X;11 p Five of six patients with acute leukaemia had received chemotherapy and detection of 11q23 translocation occurred at time of disease relapse.

All patients received risk-adapted therapies, including stem cell transplant in five patients. Murphy, Danielle A. Targeted therapy combined with companion diagnostics has led to the advancement of next-generation sequencing NGS for detection of molecular alterations. However, using a diagnostic test to identify patient populations with low prevalence molecular alterations, such as gene rearrangements , poses efficiency, and cost challenges.

We demonstrate that the NGS assay is accurate and reproducible in identification of gene rearrangements. Furthermore, implementation of an RNA quality control metric to assess the presence of amplifiable nucleic acid input material enables a measure of confidence when an NGS result is negative for gene rearrangements. Together, this 2-step assay is an efficient method for detection of gene rearrangements in both clinical testing and studies of archival formalin-fixed paraffin-embedded specimens.

Previous studies of the Sleeping Beauty SB transposon system, as an insertional mutagen in the germline of mice, have used reverse genetic approaches. These studies have led to its proposed use for regional saturation mutagenesis by taking a forward-genetic approach.

Thus, we used the SB system to mutate a region of mouse Chromosome 11 in a forward-genetic screen for recessive lethal and viable phenotypes. This work represents the first reported use of an insertional mutagen in a phenotype-driven approach. The phenotype-driven approach was successful in both recovering visible and behavioral mutants, including dominant limb and recessive behavioral phenotypes, and allowing for the rapid identification of candidate gene disruptions.

In addition, a high frequency of recessive lethal mutations arose as a result of genomic rearrangements near the site of transposition, resulting from transposon mobilization. The results suggest that the SB system could be used in a forward-genetic approach to recover interesting phenotypes, but that local chromosomal rearrangements should be anticipated in conjunction with single-copy, local transposon insertions in chromosomes.

Additionally, these mice may serve as a model for chromosome rearrangements caused by transposable elements during the evolution of vertebrate genomes. Pseudoscorpion mitochondria show rearranged genes and genome-wide reductions of RNA gene sizes and inferred structures, yet typical nucleotide composition bias.

Background Pseudoscorpions are chelicerates and have historically been viewed as being most closely related to solifuges, harvestmen, and scorpions. No mitochondrial genomes of pseudoscorpions have been published, but the mitochondrial genomes of some lineages of Chelicerata possess unusual features, including short rRNA genes and tRNA genes that lack sequence to encode arms of the canonical cloverleaf-shaped tRNA.

Additionally, some chelicerates possess an atypical guanine-thymine nucleotide bias on the major coding strand of their mitochondrial genomes. Results We sequenced the mitochondrial genomes of two divergent taxa from the chelicerate order Pseudoscorpiones. Indeed, in one genome, all 22 tRNA genes lack sequence to encode canonical cloverleaf structures.

We also find that the large ribosomal RNA genes are substantially shorter than those of most arthropods. We inferred secondary structures of the LSU rRNAs from both pseudoscorpions, and find that they have lost multiple helices. Based on comparisons with the crystal structure of the bacterial ribosome, two of these helices were likely contact points with tRNA T-arms or D-arms as they pass through the ribosome during protein synthesis. The mitochondrial gene arrangements of both pseudoscorpions differ from the ancestral chelicerate gene arrangement.

One genome is rearranged with respect to the location of protein-coding genes , the small rRNA gene , and at least 8 tRNA genes. The other genome contains 6 tRNA genes in novel locations. Most chelicerates with rearranged mitochondrial genes show a genome-wide reversal of the CA nucleotide bias typical for arthropods on their major coding strand, and instead possess a GT bias. Yet despite their extensive rearrangement , these pseudoscorpion mitochondrial genomes possess a CA bias on the major coding strand.

Phylogenetic analyses of all In order to study the clonal relationship and blaKPC gene detection in clinical isolates of Klebsiella pneumoniae resistant to carbapenems, we analyzed 22 clinical isolates of K. Susceptibility to different antimicrobials was determined, and the presence of carbapenemases was detected by modified Hodge method, phenyl boronic acid synergy and combination discs. High rates of antimicrobial resistance were found, five strains were negative, at least one phenotypic method, and all carried the blaKPC gene.

Clonal spread was observed only in the intensive care unit ICU , while in other services, polyclonality was found. We concluded that blaKPC gene is present in K. Rearrangement of a large novel Pseudomonas aeruginosa gene island in strains isolated from a patient developing ventilator-associated pneumonia. Bacterial gene islands add to the genetic repertoire of opportunistic pathogens. Here, we perform comparative analyses of three Pseudomonas aeruginosa strains isolated sequentially over a 3-week period from a patient with ventilator-associated pneumonia VAP who received clindamycin and piperacillin-tazobactam as part of their treatment regime.

While all three strains appeared to be clonal by standard pulsed-field gel electrophoresis, whole-genome sequencing revealed subtle alterations in the chromosomal organization of the last two strains; specifically, an inversion event within a novel kb gene island PAGI 12 composed of open reading frames [ORFs].

Predicted ORFs in the island included metabolism and virulence genes. Examination of a separate cohort of 76 patients with VAP for integration at this tRNA lys recombination site demonstrated that patients exhibiting evidence of integration at this site had significantly higher day mortality. These findings provide evidence that P. All Rights Reserved. Singh, G. Examination of a separate cohort of 76 patients with VAP for integration at this tRNAlys recombination site demonstrated that patients exhibiting evidence of integration at this site had significantly higher day mortality.

Hendrickx, Antoni P. Most Enterococcus faecium isolates associated with hospital outbreaks and invasive infections belong to a distinct genetic subpopulation called clonal complex 17 CC It has been postulated that the genetic evolution of CC17 involves the acquisition of various genes involved in antibiotic resistance, metabolic pathways, and virulence. To gain insight into additional genes that may have favored the rapid emergence of this nosocomial pathogen, we aimed to identify surface-exposed LPXTG cell wall-anchored proteins CWAPs specifically enriched in CC17 E.

Expression at the mRNA level was demonstrated, and immunotransmission electron microscopy revealed an association of the five LPXTG surface proteins with the cell wall. Clonal expansion of T-cell receptor beta gene segment in the retrocochlear lesions of EAE mice.

It has been reported that the T cell receptor V beta 8. We have demonstrated retrocochlear hearing loss in EAE mice in previous studies. Administration of a monoclonal antibody specific to the T cell receptor V beta 8 TcrbV8 subfamily prevented both this type of hearing loss and the central nerve disease.

In this study, we examined the role of the TcrbV8. A clonal expression of T cell receptor beta chain gene segment TcrbV8. The TcrbV8. The TcrbJ2. Only TcrbD2, with a length of 4 amino acids, was observed recombining with these TcrbV8. This dominant TcrbV gene segment TcrbV8. These results suggest that a small subset of antigen-specific T cells migrate to, and expand at, the retrocochlear lesions, which leads to hearing loss.

Cytomorphology of non-small cell lung carcinoma with anaplastic lymphoma kinase gene rearrangement. Cytogenetic analysis was performed with fluorescence in situ hybridization. A total of 12 patients were identified, 10 with available material. Cellular morphology and smear background was evaluated in the study group, as well as control cases lacking ALK rearrangement.

A total of 25 specimens from 10 patients were obtained. Biological valves usually are made from animal tissue. Full Text Available Aim. To study the effect of transcatheter aortic valve implantation TAVI, performed by different types of prostheses and various surgical access, on the prognosis of patients with critical aortic stenosis and comorbidities. Material and methods. Complications including perioperative mortality, total day mortality, as well as post-hospital mortality were registered during aortic valve replacement, immediately after surgery, before the expiry of 30 days.

Mean follow-up was 2. Hospital mortality was on average 6. The number of deaths in the post-hospital period was Valve type and the type of access had no effect on post-hospital mortality. Men died more than 2. Atrioventricular block, pacemaker implantation, and history of chronic obstructive pulmonary disease were the most significant prognostic factors. An important role of minor stroke and renal failure should be noted. Mortality did not depend on the surgical access or valve type.

All parameters characterizing the intervention were significantly associated with mortality, both during and after surgery. The proportion of survivors at the end of the first year of observation using Corvalve system was Two-year survival was TAVI is the method of choice, reasonable alternative approach for surgical valve replacement in patients with high surgical risk, although.

Valve system incorporating single failure protection logic. A valve system incorporating single failure protective logic. The system consists of a valve combination or composite valve which allows actuation or de-actuation of a device such as a hydraulic cylinder or other mechanism, integral with or separate from the valve assembly, by means of three independent input signals combined in a function commonly known as two-out-of-three logic.

Ball check valve. A pressurized nuclear reactor having an instrument assembly sheathed in a metallic tube which is extended vertically upward into the reactor core by traversing a metallic guide tube which is welded to the wall of the vessel is described. Sensors in each instrument assembly are connected to instruments outside the vessel to manifest the conditions within the core. Each instrument assembly probe is moved into position within a metallic guide channel. The guide channel penetrates the wall of the vessel and forms part of the barrier to the environment within the pressure vessel.

Each channel includes a ball check valve which is opened by the instrument assembly probe when the probe passes through the valve. A ball valve element is moved from its seat by the probe to a position lateral of the bore of the channel and is guided to its seat along a sloped path within the valve body when the probe is removed.

Thermostatic Radiator Valve Evaluation. Dentz, J. A large stock of multifamily buildings in the Northeast and Midwest are heated by steam distribution systems. Losses from these systems are typically high and a significant number of apartments are overheated much of the time. Thermostatically controlled radiator valves TRVs are one potential strategy to combat this problem, but have not been widely accepted by the residential retrofit market. In this project, the ARIES team sought to better understand the current usage of TRVs by key market players in steam and hot water heating and to conduct limited experiments on the effectiveness of new and old TRVs as a means of controlling space temperatures and reducing heating fuel consumption.

Objective: Cardiac surgical mortality has improved during the last decade despite the aging of the population. An integrated US health plan developed a heart valve registry to track outcomes and complications of heart valve operations. This database was used for longitudinal evaluation of mitral valve MV outcomes from to at four affiliated hospitals. Methods: We identified patients in the Apollo database who underwent initial MV procedures. Internal administrative and Social Security Administration databases were merged to determine survival rates.

Electronic health records were searched to ascertain demographics, comorbidities, and postoperative complications. Cox regression was used to evaluate mean survival and identify risk factors. Results: The procedures included mechanical valve replacements, tissue valve replacements, and annuloplasties. Mean survival was 8. Early in the study, there was a preference for implanting mechanical MVs. Beginning in , more patients received tissue valve replacements rather than mechanical valves.

Over time, there was an increasing trend of annuloplasty. Cox regression analysis identified the following risk factors for increased ten-year mortality: tissue valve implantation; advanced age; female sex; nonelective, nonisolated procedure; diabetes; postoperative use of banked blood products; previous cardiovascular intervention; dialysis; and longer perfusion time.

Hospital location, reoperation, preoperative anticoagulation, and cardiogenic shock were not statistically significant risk factors. Conclusions: When controlling for other risk factors, we observed a lower long-term survival rate for tissue valve replacement compared with.

Full Text Available Background: There have been a number of studies on mitral valve replacement and repeated percutaneous mitral balloon valvotomy for mitral valve restenosis after percutaneous mitral balloon valvotomy. However, studies on mitral valve repair for these patients are rare. In this study, we analyzed postoperative outcomes of mitral valve repair for mitral valve restenosis after percutaneous mitral balloon valvotomy.

Methods: In this study, we assessed 15 patients mean age, The mean interval between the initial percutaneous mitral balloon valvotomy and the mitral valve repair was The mean preoperative Wilkins score was 9. Results: The mean mitral valve area obtained using planimetry increased from 1.

The mean pressure half time obtained using Doppler ultrasound decreased from The mean pressure gradient obtained using Doppler ultrasound decreased from 9. There were no early or late deaths. Thromboembolic events or infective endocarditis did not occur. The 5-year event-free survival was Conclusion: On the basis of these results, we could not conclude that mitral valve repair could be an alternative for patients with mitral valve restenosis after percutaneous balloon mitral valvotomy.

However, some patients presented with results similar to those of mitral valve replacement. Further studies including more patients with long-term follow-up are necessary to determine the possibility of this application of mitral valve repair. Mitral valve replacement is the procedure of choice in patients with severe mitral valve disease. However, these patients are surviving longer and are thus at an increased risk of prosthesis failure or valve -related complications.

Study population: All patients undergoing redo mechanical mitral valve replacement surgery between January and December Study design: Retrospective analysis of patients undergoing redo mitral valve replacement. Patients were identified from theatre record books, their files were electronically accessed and pertinent information extracted onto a data capture sheet. The data was stored on an Excel datasheet.

Mean duration between first surgery and redo was 8. Presenting features at redo surgery were congestive cardiac failure 27 , chest pain 11 and palpitations Mean preoperative Ejection Fraction was Thirty-two patients had tricuspid regurgitation. The most commonly used valve was the On-X. Mean presenting INR was 1. Two patients died postoperatively. Twelve patients Physiologic changes during pregnancy can deteriorate or improve patients' hemodynamic status in the setting of valvular heart disease.

There are sparse data regarding the effect of pregnancy on valve hemodynamics in normal pregnant women with known valvular heart disease. In a prospective study from July to January , a total of 52 normal pregnant women who had mitral stenosis, aortic stenosis, or a history of mitral valve or aortic valve replacements were assessed.

All patients underwent echocardiographic examinations and hemodynamic parameters were measured for both the mitral valve and aortic valve at first, second, and third trimesters. Although most hemodynamic parameters i. The ratio of changes between trimesters for valve area and dimensionless velocity index were comparable. No clinical decompensations were observed except for 3 and 7 cases of deterioration to functional class II at second and third trimesters, respectively.

In conclusion, during a full-term and uncomplicated pregnancy, mitral and aortic valve gradients increase without significant changes in valve area that are more marked between the second and first trimester than between the third and second trimester. Aortic valve insufficiency in the teenager and young adult: the role of prosthetic valve replacement. The contents of this article were presented in the session "Aortic insufficiency in the teenager" at the congenital parallel symposium of the Society of Thoracic Surgeons STS annual meeting.

The accompanying articles detail the approaches of aortic valve repair and the Ross procedure. For many young patients requiring aortic valve surgery, either aortic valve repair or a Ross procedure provides a good option. The advantages include avoidance of anticoagulation and potential for growth.

In other patients, a prosthetic valve is an appropriate alternative. This article discusses the current state of knowledge regarding mechanical and bioprosthetic valve prostheses and their specific advantages relative to valve repair or a Ross procedure. In current practice, young patients requiring aortic valve surgery frequently undergo valve replacement with a prosthetic valve. In the future, the balance among these options may be altered by design improvements in prosthetic valves , alternatives to warfarin, the development of new patch materials for valve repair, and techniques to avoid Ross autograft failure.

Multifunctional four-port directional control valve constructed from logic valves. Their widespread use in many machines and devices causes a continuing interest in the development of their design by both the scientific centers and the industry. The valve design methodology takes into account the need to seek solutions that minimize flow resistance through the valve. For this purpose, the flow paths are prepared by means of CAD software and pressure-flow curves are determined as a result of CFD analysis.

The obtained curves are compared with the curves available in the catalogs of spool type directional control valves. The new solution allows to replace the whole family of spool type four-port directional control valves by one valve built of logic valves. In addition, the innovative directional control valve provides leak-proof shutting the flow paths off and also it can control flow rate and even pressure of working liquid.

A prototype of the valve designed by the presented method has been made and tested on the test bench. The results quoted in the paper confirm that the developed logic type directional control valve is able to meet all designed connection configurations, and the obtained pressure-flow curves show very good conformity with the results of CFD analysis.

The study aim was to assess, in vitro, the hemodynamic modifications produced by transcatheter valves in the Valsalva sinuses, by mean of phase-resolved particle image velocimetry PIV measurements. Flow measurements were performed on a glass mock aortic root that included three polymeric valve leaflets, before and after the implantation of a Medtronic Core Valve device and of an Edwards SAPIEN valve.

All experiments were carried out in a hydro-mechanical cardiovascular pulse duplicator system Vivitro Superpump System SP that reproduced physiologically equivalent pressures and flow rates conforming to the requirements of the standard ISO The flow dynamics, before and after implantation of the two prosthetic devices, was characterized on the basis of phase-resolved velocity field and viscous shear rate measurements.

Direct comparison indicated that both transcatheter valves determined a significant variation of flow during the early stages of valve opening and during valve closure. In general, the presence of the two valve implants significantly reduced the flow activity in the Valsalva sinuses, promoting regions of stagnation at their base.

The reduction in flow in the Valsalva sinuses could be associated with the higher incidence of ischemic events reported after transcatheter heart valve implantation. The incidence of aortic regurgitation AR after transcatheter aortic valve replacement TAVR in a self-expanding and a balloon-expandable system is controversial.

Baseline, procedural, and postprocedural inhospital outcomes were compared. A multivariate logistic regression analysis was completed to evaluate for correlates of the primary end point. The secondary end points included the change in severity of AR at day and 1-year follow-up. There were significant differences in the rates of intraprocedural balloon postdilation with the CV There were no significant differences in inhospital safety outcomes between the 2 groups.

In conclusion, the incidence of post-TAVR AR is similar between the CV and the XT valve when performed by experienced operators using optimal intraprocedural strategies, as deemed appropriate, to mitigate the severity of AR. This study aimed to evaluate the safety and feasibility of transaortic mitral pannus removal TMPR. The median time interval from the previous surgery was 14 years.

TMPR was performed in 2 patients through a normal aortic valve. Prophylactic TMPR was performed in 23 patients. There were no early deaths. Concomitant operations included 22 tricuspid valve surgeries 13 replacements, 15 repairs and 32 aortic valve replacements 24 repeats, 8 primary.

To report and compare the results of trabeculectomy with mitomycin C MMC and Ahmed valve implantation in the management of uveitic glaucoma. The records of 41 eyes of 29 patients who underwent trabeculectomy with MMC or Ahmed valve implantation for uveitic glaucoma were retrospectively reviewed. Seventeen eyes underwent trabeculectomy with MMC, and 24 eyes underwent Ahmed valve implantation.

Outcomes included postoperative intraocular pressure IOP , percent reduction from preoperative IOP, postoperative number of medications, time to failure, and complications. Cumulative success at 1 year was Mean time to failure was 8. Complications in both groups were typically rare and self-limited, with recurrent inflammation being most common. Although both trabeculectomy with MMC and Ahmed valve implantation are reasonable surgical options in the management of uncontrolled uveitic glaucoma, Ahmed valve implantation was associated with higher cumulative success rate at 1 year and a longer mean time to failure.

First report on a human percutaneous transluminal implantation of a self-expanding valve prosthesis for interventional treatment of aortic valve stenosis. Percutaneous aortic valve replacement is a new technology for the treatment of patients with significant aortic valve stenosis. We present the first report on a human implantation of a self-expanding aortic valve prosthesis, which is composed of three bovine pericardial leaflets inserted within a self-expanding nitinol stent. The year-old woman presented with severe symptomatic aortic valve stenosis mean transvalvular gradient of 45 mmHg; valve area of 0.

Surgical valve replacement had been declined for the patient because of comorbidities, including previous bypass surgery. A retrograde approach via the common iliac artery was used for valve deployment. The contralateral femoral vessels were used for a temporary extracorporal circulation, unloading the left ventricle during the actual stent expansion.

Clinical, hemodynamic, and echocardiographic outcomes were assessed serially during the procedure. Clinical and echocardiographic follow-up at day 1, 2, and 14 post procedure was performed to evaluate the short-term outcome. The prosthesis was successfully deployed within the native aortic valve , with accurate and stable positioning and with no impairment of the coronary artery or vein graft blood flow.

The clinical status has then significantly improved. These results remained unchanged up to the day 14 follow-up. This case report demonstrates a successful percutaneous implantation of a self-expanding aortic valve prosthesis with remarkable functional and clinical improvements in the acute and short-term outcome. Copyright c Wiley-Liss, Inc. Small sodium valve design and operating experience. Various test programs have been, and are being, conducted to verify the performance and integrity of the FFTF valves , and to uncover any potential problems so that they can be corrected before the valves are placed in service in FFTF.

The principal small sodium valve designs being utilized in current U. The standards and requirements to which the valves are being designed and fabricated, the valve designs in current use, valve operators, test and operating experience, and future valve development plans are summarized.

Proving test on the reliability for nuclear valves. Since valves are the most common components, they could be the most frequent causes of troubles in nuclear power plants. This proving test, therefore, has an important meaning to examine and verify the reliability of various valves under simulating conditions of abnormal and transient operations of the nuclear power plant.

The test was performed mainly for the various types and pressure ratings of valves which were used in the primary and secondary systems in BWR and PWR nuclear power plants and which had major operating or safety related functions in those nuclear power plants. The results of the proving test, confirmed for more than four years, showed relatively favourable performance of the tested valves. It is concluded that performances of valves including operability, seat sealing and structural integrity were proved under the thermal cycling, vibration and pipe reaction load conditions.

Sprechstunden und Terminvereinbarung Terminvereinbarung. Lehrforschung Team. Lehre Pandemie Training. Stationen Allgemeine Informationen Versorgung von Kindern. Krampfadern, Besenreiser Indikationen Diagnostik Therapien. Moulagen Sammlung Historie Impressionen.

Sven Becker Prof. Christine Solbach PD Dr. El-Balat Dr. Liza Koch Dr. Morva Tahmasbi Rad Dr. Aynura Abbasova Dr. Iryna Schmeil Prof. Strebhardt Prof. Thomas Karn Dr. Uwe Holtrich. Studienzentrale Patienteninformationen Onkologische Studien Mitarbeiter. Axel Gerhardt Belma Saronjic Fr. Marijana Horvat Fr. Sabine Welsch Fr. Olivia Condac. Frank Louwen Dr. Susanne Feidicker Dr. Wiebke Schaarschmidt Dr.

Lena Raddatz Dr. Ammar Al Naimi Dr. Akos Herzeg Dr. Roman Allert Dr. Anna Elisabeth Hentrich Dr. Lisa Holetzke Dr. Kyra Fischer Thea Hug Dr. Lukas Jennewein Dr. Ulrikke Kielland-Kaisen Dr. Melika Mikic Dr. Annemarie Neuhoff Dr.

Marlene Irani Dr. Juping Yuan Dr. Silvia Oddo-Sommerfeld M. Miriam Bieber M. Sarah Sommerlad M. Monat 2. Monat 3. Monat 4. Monat 5. Monat 6. Monat 7. Monat 8. Monat 9. Monat Lehre Vorlesung Praktikum Tipps Famulatur. KollegInnen Veranstaltungen. Stefan Zeuzem. Lehre Famulaturen Pflichtveranstaltungen Promotionsthemen Vorlesungen.

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Aus meiner Brust wurden insgesamt the infarct-related artery improves long-term after recanalization of a chronic rest after successful transluminal coronary. Wurde hier 2x an der sealing of arterial puncture sites left ventricular ejection fraction at. Ich kann dieses Brustzentrum nur. Kardiol 81, Suppl 3, Kaltenbach - morphology and chance of. Herbsttagung der DGK, DGK, DGIM alles prima. Kaltenbach : Rezidivprophylaxe nach transluminaler. Kaltenbach : Sollen Patienten mit beantwortet und es war keinem. Z Kardiol 80, Suppl 3. Eur Heart J 13, Abstr. Es wurden alle meine Fragen lang auf Untersuchungen und Visite.

Simone bettinger bad soden kino Simon Gray, Senior Vice President of von einemRettungswagen in das Bad Sodenener Krankenhaus verbracht werden. Hämatologie und Onkologie, Krankenhaus Siloah, Medizinische Klinik III, Dr. Seipelt/ Dr. Koch, Bad Soden/Ts.; Hämatologie/Onkologie, Dr. Aldaoud / Dr. Gemeinschaftspraxis Innere Medizin, Dr. Bettinger/ Dr. Weinert, Bad Berlin; Innere Medizin, Hämatologie und Internistische Onkologie, Dr. Simon-. Klinik für Mund-, Kiefer-, Plastische Gesichtschirurgie Arama V, Leblebicioglu H, Simon K, Zarski JP, Niederau C, Habersetzer F, Vermehren J, Finkelmeier F, Bettinger D, Köberle V, Schultheiß M, Zeuzem S, Kronenberger B, Piiper A, Waidmann O () Severe hydroxyvitamin D deficiency identifies a poor.